GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9309473 | 1 | rs56672945 | chr2:73622663 | NAT8 | chr2:73867850-73869537:- | 0.39 | 6.11 | 2.09E-9 | Metabolite levels |
| THCA | cis | rs56702977 | 1 | rs56702977 | chr15:42671308 | LRRC57 | chr15:42834722-42841002:- | 0.19 | 3.81 | 0.000155 | Fibrinogen levels |
| THCA | cis | rs6911965 | 1 | rs56763150 | chr6:24482999 | GPLD1 | chr6:24428405-24489850:- | 0.2 | 3.75 | 0.0002 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs56763150 | chr6:24482999 | MRS2 | chr6:24403153-24425809:+ | 0.24 | 5.35 | 1.35E-7 | Hematological and biochemical traits |
| THCA | cis | rs477692 | 1 | rs567700 | chr10:131423126 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.31 | 1.9E-26 | Response to temozolomide |
| THCA | cis | rs56775891 | 1 | rs56775891 | chr18:77575613 | C18orf22 | chr18:77794358-77853788:+ | 0.14 | 3.69 | 0.000249 | Schizophrenia |
| THCA | cis | rs9815354 | 1 | rs56776628 | chr3:41866856 | ULK4 | chr3:41288091-42003660:- | 1.05 | 19.9 | 1.26E-64 | Diastolic blood pressure |
| THCA | cis | rs2288884 | 1 | rs56808319 | chr19:52577874 | ZNF432 | chr19:52536678-52552073:- | -0.18 | -4.57 | 6.29E-6 | Bronchodilator response in asthma (inhaled corticosteroid treatment interaction) |
| THCA | cis | rs1171113 | 1 | rs568129 | chr6:84229114 | SNAP91 | chr6:84262607-84419127:- | -0.18 | -3.71 | 0.000232 | Bipolar disorder with mood-incongruent psychosis |
| THCA | cis | rs4038131 | 1 | rs56818101 | chr2:17776053 | GEN1 | chr2:17935162-17966632:+ | 0.51 | 6.86 | 2.08E-11 | Psychosis and Alzheimer's disease |
| THCA | cis | rs2686555 | 1 | rs568489 | chr12:121094241 | P2RX4 | chr12:121647664-121671907:+ | 0.16 | 3.48 | 0.00055 | C-reactive protein levels or triglyceride levels (pleiotropy) |
| THCA | cis | rs73201462 | 1 | rs56850662 | chr3:128061922 | EEFSEC | chr3:127872313-128127488:+ | -0.23 | -3.99 | 7.56E-5 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs568617 | 1 | rs568617 | chr11:65653242 | CTSW | chr11:65647284-65651212:+ | -0.6 | -15.88 | 6.69E-46 | Crohn's disease |
| THCA | cis | rs568617 | 1 | rs568617 | chr11:65653242 | SNX32 | chr11:65601410-65621170:+ | 0.63 | 9.47 | 1.33E-19 | Crohn's disease |
| THCA | cis | rs12908161 | 1 | rs56864281 | chr15:85357649 | GOLGA6L5 | chr15:85047738-85060078:- | -0.15 | -4 | 7.44E-5 | Schizophrenia |